NORVERAPAMIL HYDROCHLORIDE

Name	Nor Verapamil Hydrochloride
Synonyms	NORVERAPAMIL HCL NORVERAPAMIL HYDROCHLORIDE Nor Verapamil Hydrochloride n-nor-(±)-verapamil hydrochloride (+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitril a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile
CAS	67812-42-4

Molecular Formula	C26H37ClN2O4
Molar Mass	477.04
Melting Point	softens at 50°C, 155-160°C dec.
Flash Point	9℃
Solubility	H2O: >10mg/mL
Appearance	solid
Color	white
Storage Condition	desiccated
Stability	Hygroscopic
In vitro study	Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil. Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.

UN IDs	UN 2811 6.1/PG 3
WGK Germany	3

Last Update：2024-01-02 23:10:35

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